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CIP4 promotes lung adenocarcinoma metastasis and is associated with poor prognosis.
Truesdell P, Ahn J, Chander H, Meens J, Watt K, Yang X, Craig AW. Truesdell P, et al. Oncogene. 2015 Jul;34(27):3527-35. doi: 10.1038/onc.2014.280. Epub 2014 Sep 1. Oncogene. 2015. PMID: 25174397 Free PMC article.
Aberrant epidermal growth factor receptor (EGFR) signaling in non-small cell lung cancer (NSCLC) is linked to tumor progression, metastasis and poor survival rates. ...CIP4 was highly expressed in a panel of NSCLC cell lines and normal lung epithelial cell lines. St …
Aberrant epidermal growth factor receptor (EGFR) signaling in non-small cell lung cancer (NSCLC) is linked to tumor progression, meta …
Defining functional interactions during biogenesis of epithelial junctions.
Erasmus JC, Bruche S, Pizarro L, Maimari N, Pogglioli T, Tomlinson C, Lees J, Zalivina I, Wheeler A, Alberts A, Russo A, Braga VM. Erasmus JC, et al. Nat Commun. 2016 Dec 6;7:13542. doi: 10.1038/ncomms13542. Nat Commun. 2016. PMID: 27922008 Free PMC article.
A partner for EEF1A in cadherin contact maintenance is the formin DIAPH2, which interacts with EEF1A. In contrast, depletion of either the endocytic regulator TRIP10 or the Rho GTPase activator VAV2 reduces E-cadherin levels at junctions. TRIP10 binds to and require …
A partner for EEF1A in cadherin contact maintenance is the formin DIAPH2, which interacts with EEF1A. In contrast, depletion of either the e …
Cdc42-interacting protein 4 silencing relieves pulmonary fibrosis in STZ-induced diabetic mice via the Wnt/GSK-3β/β-catenin pathway.
Zhang X, Liu Y, Shao R, Li W. Zhang X, et al. Exp Cell Res. 2017 Oct 1;359(1):284-290. doi: 10.1016/j.yexcr.2017.07.018. Epub 2017 Jul 16. Exp Cell Res. 2017. PMID: 28720386
Here, diabetes was induced by streptozotocin (STZ), and later lung tissue was collected and subjected to hematoxylin and eosin (H & E) staining for morphological examination. ...However, beta-catenin overexpression ameliorated the inhibitory effect of CIP4 down-regulat …
Here, diabetes was induced by streptozotocin (STZ), and later lung tissue was collected and subjected to hematoxylin and eosin (H &am …
CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis.
Cerqueira OL, Truesdell P, Baldassarre T, Vilella-Arias SA, Watt K, Meens J, Chander H, Osório CA, Soares FA, Reis EM, Craig AW. Cerqueira OL, et al. Oncotarget. 2015 Apr 20;6(11):9397-408. doi: 10.18632/oncotarget.3351. Oncotarget. 2015. PMID: 25823823 Free PMC article.
In mammary orthotopic xenograft assays using both human TNBC cells (MDA-MB-231, HCC 1806) and rat MTLn3 cells, CIP4 silencing had no overt effect on tumor growth, but significantly reduced the incidence of lung metastases in each tumor model. In human invasive breast cance …
In mammary orthotopic xenograft assays using both human TNBC cells (MDA-MB-231, HCC 1806) and rat MTLn3 cells, CIP4 silencing had no overt e …
Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms.
Wang L, Rudert WA, Grishin A, Dombrosky-Ferlan P, Sullivan K, Deng X, Whitcomb D, Corey S. Wang L, et al. Biochem Biophys Res Commun. 2002 May 24;293(5):1426-30. doi: 10.1016/S0006-291X(02)00398-4. Biochem Biophys Res Commun. 2002. PMID: 12054674
A fourth, relatively abundant transcript (CIP4h) was isolated from heart, lung, and trachea tissue. CIP4h retains the SH3 domain. CIP4 levels are modified by all-trans-retinoic acid. ...
A fourth, relatively abundant transcript (CIP4h) was isolated from heart, lung, and trachea tissue. CIP4h retains the SH3 domain. CIP …